HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-fluoro-3,4-dihydro-2-phenyl-1(2H)-naphthalenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Methyl 6-fluoro-1,2,3,4-tetrahydro-1-oxo-2-phenyl-2-naphthalenecarboxylate | HCID 57050899 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-fluoro-3,4-dihydro-2-phenyl-1(2H)-naphthalenone | HCID 13953433 | 87% |
Reaction Conditions
| Temperature | 150 °C |
|---|
Reaction Steps
The tetralone from Step B (2.8 g, 9.4 mmole) was dissolved in 45 ml of dimethylformamide. To this solution was added lithium chloride (2.0 g, 47 mmole) and water (0.42 ml, 23 mmole). The reaction mixture was heated to 150° C. for 2.5 hrs and then cooled and partitioned between ether and water. The aqueous Phase was separated and extracted three times with ether. The combined organic phases were washed once with water, dried (MgSO4), and concentrated (1.96 g, 87% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05182303 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-c482adfbbac4421e922c5d0c9fb93a29 |
| Source note | uspto-grants-1993_01 |