1,1'-Carbonyldiimidazole → HCID 19926436, compound

Participants

Reaction Steps

A stirred solution of 2-bromophenylacetic acid (28.4 g, 132 mmol) in chloroform (200 ml) was treated dropwise over 10 rain with 1,1'-carbonyldiimidazole (21.4 g, 132 mmol) in chloroform (120 ml) under argon, after 1 h treated with 2-(methoxyphenyl)piperazine (24.4 g, 127 mmol) in chloroform (100 ml), after 18 h washed with 0.5 N-HC1 (2×200 ml), 0.5 N-NaOH (2×200 ml), and brine (200 ml), dried (MgSO4), and evaporated in vacuo. The oil was crystallised by trituration with cyclohexane (100 ml) to give the product (27.0 g), m.p. 95°-97°.

Provenance & Evidence