Hydrochloric Acid → HCID 15228848, compound

Participants

Reaction Steps

A stirred solution of the product of Example 1 (25.7 g, 66.1 mmol) in dry tetrahydrofuran (THF, 100 ml) was heated under reflux under an atomosphere of argon, treated dropwise over 25 min with borane-dimethylsulphide (12.5 ml, 131.7 mmol) in THF (100 ml), after 90 min cooled to room temperature, and the suspension treated dropwise with methanol (100 ml), followed by concentrated hydrochloric acid (50 ml). The solution was stirred for 1 h and the precipitate filtered and washed with acetonitrile (20 ml) and ether (3×20 ml) to give the product (15.7 g) m.p. 190°-195°.

Provenance & Evidence