HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → t-Butyl [(RS)-2-[[(S)-2-[(benzyloxy)carbonyl]-1-carbamoylethyl]-carbamoyl]propyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid | HCID 4192640 | — |
| Reactant | Benzyl (S)-3-(1-t-butoxyformamido)succinamate | HCID 10615806 | — |
| Product | t-Butyl [(RS)-2-[[(S)-2-[(benzyloxy)carbonyl]-1-carbamoylethyl]-carbamoyl]propyl]carbamate | HCID 86747430 | — |
Reaction Steps
Benzyl (S)-3-(1-t-butoxyformamido)succinamate was deprotected using trifluoroacetic acid and then coupled with DL-N-(t-butoxycarbonyl)-2-methyl-β-alanine to yield t-Butyl [(RS)-2-[[(S)-2-[(benzyloxy)carbonyl]-1-carbamoylethyl]-carbamoyl]propyl]carbamate, m.p. 135°-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430024 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-c049750661134aa89d29afc5afd9a047 |
| Source note | uspto-grants-1995_07 |