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Piperazine → Benzyl [2-(4-piperazinylcarbonyl)ethyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperazine | HCID 4837 | — |
| 反応物 | N-Benzyloxycarbonyl-beta-alanine | HCID 75313 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Benzyl [2-(4-piperazinylcarbonyl)ethyl]carbamate | HCID 53819799 | 86.2% |
反応手順
2.23 g of N-benzyloxycarbonyl-β-alanine was coupled with 2.58 g of piperazine. The evaporation residue was suspended in THF, the undissolved material was filtered off and the filtrate was evaporated. Chromatography of the residue on silica gel RP 18 using water/methanol (2-5%) gave 2.51 g of benzyl [2-(4-piperazinylcarbonyl)ethyl]carbamate, MS: 291 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05430024 |
| 出典データセット | uspto-grants-1995_07 |
| ORD ID | ord-fcf916dbbeb544cba129b75e11beadd2 |
| 出典メモ | uspto-grants-1995_07 |