HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131718329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| Reactant | HCID 126482907 | HCID 126482907 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 131718329 | HCID 131718329 | 84.6% |
Reaction Steps
Boc-L-Leu-OH (1.30 g), HCl.H-D-Trp(CH3)-OBzl (1.76 g), WSCD (950 mg) and HOBT (827 mg) in DMF (30 ml) was reacted at 5° C. overnight in a similar manner to that of Preparation 1-1) to give Boc-L-Leu-D-Trp(CH3)-OBzl (2.48 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430022 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-23a2ee9b83714009a2ffd7c56fa75694 |
| Source note | uspto-grants-1995_07 |