HCID 131718329, compound → HCID 126483389, compound

HRID 1647128Notes

Reaction equation

HRID 1647128 reaction equation
[NH:1]([C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C@H:2]([C:7]([NH:9][C@@H:10]([C:22]([O:24]CC1C=CC=CC=1)=[O:23])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]([CH3:21])[CH:13]=1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]>CO.O.[Pd]>[NH:1]([C:32]([O:34][C:35]([CH3:37])([CH3:36])[CH3:38])=[O:33])[C@H:2]([C:7]([NH:9][C@@H:10]([C:22]([OH:24])=[O:23])[CH2:11][C:12]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]([CH3:21])[CH:13]=1)=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5]

Participants

5

Reactant 1

HCID 131718329HCID 131718329, compound

Product 1

HCID 126483389HCID 126483389, compoundYield 98.2%

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Boc-L-Leu-D-Trp(CH3)-OBzl (2.40 g) in MeOH (50 ml) and water (1 ml) was hydrogenated over 10% palladium on carbon in a similar manner to that of Preparation 1-4) to give Boc-L-Leu-D-Trp(CH3)-OH (1.95 g).

Workup

  1. customof Preparation 1-4)

Sources & evidence

ORD record
ord-da4c0a6b164c43448809c6efa016e0fc
Source dataset
uspto-grants-1995_07
Patent number
US05430022

Reaction notes

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