反应详情

A mixture of 3-(3-hydroxy-1-propoxy)-2-methyl-4-pyrone {1.4 g, 7.6 mmol), 85% KOH (0.55 g, 8.4 mmol) and methyliodide (11 g, 76 mmol) was stirred at room temperature for one day. The red solution was partitioned between methylene chloride and half saturated aqueous ammoniumchloride solution. The organic phase was washed with water, dried over Na2SO4 and evaporated. The residue was purified by chromatography on silica gel with methanol/methylene chloride (3:97) as eluent. Removing the eluent by film evaporation afforded 0.31 g (20%) of the desired product as an oil.

1. customThe red solution was partitioned between methylene chloride and half saturated aqueous ammoniumchloride solution
2. washThe organic phase was washed with water
3. dry with materialdried over Na2SO4
4. customevaporated
5. customThe residue was purified by chromatography on silica gel with methanol/methylene chloride (3:97) as eluent
6. customRemoving the eluent
7. customby film evaporation