反应详情

温度

110 °C

2-Methyl-3,4-methylenedioxypyridine-N-oxide (120 mg, 0.78 mmol) was dissolved in acetic anhydride (10 ml) and the solution was heated at 110° C. for 15 min, whereupon the mixture was concentrated under reduced pressure. The residue was dissolved in methanol (20 ml) and sodium hydroxide (3 drops, 6M) was added. After 30 min at ambient temperature the mixture was neutralised with acetic acid (pH 6) and concentrated under reduced pressure. The residue was chromatographed on silica (hexane/ethyl acetate, 1:1). Yield: 90 mg (75%) of the title compound.

1. concentrationwas concentrated under reduced pressure
2. dissolutionThe residue was dissolved in methanol (20 ml)
3. additionsodium hydroxide (3 drops, 6M) was added
4. concentrationconcentrated under reduced pressure
5. customThe residue was chromatographed on silica (hexane/ethyl acetate, 1:1)