Triethylamine → HCID 18989498, compound

Participants

Reaction Steps

To 10.0 g (0.07 mole) 4-cyanophenyl isocyanate in mL methylene chloride at 23° C. was added with stirring 15.2 g (0.07 mole) 3-bromopropylalanine hydrobromide. To this was added 7.08 g (0.07 mole) triethylamine via syringe. After the addition was complete the reaction was allowed to proceed for one hour. The reaction mixture was diluted with ethyl acetate, washed with saturated sodium bicarbonate (2×50 mL), dilute aqueous hydrochloric acid, dried (Na2SO4) and concentrated to give 13.8 g (85%) of desired N-4-cyanophenyl-N'-3-bromopropyl urea contaminated with 15% isocyanate dimer.

Provenance & Evidence