2-Naphthoxyacetic acid → 1,2,3,4-tetrahydro-5-methoxy-N-[2-(2-naphthalenyloxy)ethyl]-N-propyl-2-naphthalenamine

Participants

Reaction Steps

In Example 29, phenoxyacetic acid was replaced with (2-naphthoxy)acetic acid and (-)-2-(N-n-propylamino)-5-methoxytetralin was replaced with (±)-2-(N-n-propylamino)-5-methoxytetralin. The resulting oil was subjected to flash chromatography (Silica: 8:2 pet ether/EtOAc) and the product showed characteristic peaks at: NMR (300 MHz, CDCl3) δ7.8-6.6(m, 10H), 4.15(t, 2H), 3.8(S, 3H), 0.9(t, 3H).

Provenance & Evidence