HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 10047017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4'-Fluoroacetophenone | HCID 9828 | — |
| Reactant | 3-Carboxybenzaldehyde | HCID 12077 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | HCID 10047017 | HCID 10047017 | 55.1% |
Reaction Steps
A solution of 3-formylbenzoic acid (1 g, 6.66 mmol), 4'-fluoroacetophenone (1.21 g, 16 mmol), and sodium hydroxide (0.66 g, 16 mmol) in 60 mL of ethanol/water (1:1) is stirred at room temperature for 3 days. The reaction mixture is acidified with concentrated hydrochloric acid, and the resulting solid is collected by filtration. Recrystallization in hot chloroform provides 1.5 g of the title compound; mp 205°-207° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430047 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-914e000505504a84bd8e11e1d9c7f342 |
| Source note | uspto-grants-1995_07 |