Cyclopentylamine → HCID 23221946, compound

HRID 1647276Notes

Reaction equation

[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1C)=[C:11](OS(O)(=O)=O)[C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:24])([F:23])[F:22])(=[O:3])[CH3:2].[CH:26]1([NH2:31])[CH2:30][CH2:29][CH2:28][CH2:27]1>>[C:1]([C:4]1[C:5](=[O:25])[NH:6][C:7]2[C:12]([C:13]=1[NH:31][CH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[C:21]([F:22])([F:23])[F:24])(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 2906Cyclopentylamine

HCID 86748764HCID 86748764, compound

Product 1

HCID 23221946HCID 23221946, compoundYield 67.1%

Procedure

3-Acetyl-6-chloro-8-trifluoromethyl-4-methylsulfoxy-2-quinolinone (3.5g, 0.01 mol) and cyclopentylamine (0.86g, 0.01 mol) were used, but the reaction was carried out as the above process of example 37 to obtain the desired product (2.5g, yield: 67 % ).

Sources & evidence

ORD record: ord-614e8dd0f5f8480db3dc619a23b35139
Source dataset: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05430153

Reaction notes

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