Phenethylamine, p-fluoro-, hydrochloride → HCID 19926869, compound

HRID 1647283Notes

Reaction equation

HRID 1647283 reaction equation
[C:1]([C:4]1[C:5](=[O:22])[NH:6][C:7]2[C:12]([C:13]=1C)=[C:11](OS(O)(=O)=O)[C:10]([Cl:20])=[CH:9][C:8]=2[CH3:21])(=[O:3])[CH3:2].Cl.[F:24][C:25]1[CH:33]=[CH:32][C:28]([CH2:29][CH2:30][NH2:31])=[CH:27][CH:26]=1>>[C:1]([C:4]1[C:5](=[O:22])[NH:6][C:7]2[C:12]([C:13]=1[NH:31][CH2:30][CH2:29][C:28]1[CH:32]=[CH:33][C:25]([F:24])=[CH:26][CH:27]=1)=[CH:11][C:10]([Cl:20])=[CH:9][C:8]=2[CH3:21])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 197725Phenethylamine, p-fluoro-, hydrochlorideHCID 19926924HCID 19926924, compound

Product 1

HCID 19926869HCID 19926869, compoundYield 77.8%

Procedure

3-Acetyl-6-chloro-8-methyl-4 -methylsulfoxy -2-quinolinone (2.98 g, 0.01 mol) and p-fluorophenethylamine hydrochloride (1.76g, 0.01 mol) were used, but the reaction was carried out as the above process of example 42 to obtain the desired product (2.9g, yield: 71%).

Sources & evidence

ORD record
ord-015b244ddfb84515ac66527ea29ac131
Source dataset
uspto-grants-1995_07
Patent number
US05430153

Reaction notes

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