HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-N-(3,4,5-trimethoxybenzyl)aniline → 4-Ethyl-N-(3,4,5-trimethoxybenzyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-N-(3,4,5-trimethoxybenzyl)aniline | HCID 373798 | — |
| Reactant | 151221-91-9 | HCID 373991 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Product | 4-Ethyl-N-(3,4,5-trimethoxybenzyl)aniline | HCID 373800 | 76.6% |
Reaction Steps
From 108b (7.0 g, 23.4 mmol) and NaBH4 (4.4 g, 117 mmol), a similar procedure as described for 109a gave 109b (5.4 g, 76.6%) as white crystals: mp 64°-6° C. after recrystallization from ethanol. 1H NMR (200 MHz, CDCl3) δ7.03 (d, J=8 Hz, 2H), 6.61 (s, 2H), 6.62 (d, J=8 Hz, 2H), 4.24 (s, 2H), 3.84 (s, 9H) 2.55 (q, J=8 Hz, 2H), 1.19 (t, J=Hz, 3H). EIMS m/e 301 (M+, 34).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430062 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-d7e9e079dc134b6b8e4bfdad99807e15 |
| Source note | uspto-grants-1995_07 |