HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-N-(3,4,5-trimethoxybenzyl)aniline → 4-(Methylsulfanyl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-N-(3,4,5-trimethoxybenzyl)aniline | HCID 373798 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 15657370 | HCID 15657370 | — |
| Product | 4-(Methylsulfanyl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline | HCID 373808 | 94.9% |
Reaction Steps
From 108e (11.0 g, 35.0 mmol) and NaBH4 (6.6 g, 175 mmol), a similar procedure as described in 109a gave 109e (10.6 g, 94.9%) as an oil: 1H NMR (200 MHz, DMSO-d6) δ7.07 (d, J=8 Hz, 2H), 6.67 (s, 2H), 6.57 (d, J=8 Hz, 2H), 6.23 (t, J=6 Hz, 1H), 4.10, (d, J=6 Hz, 2H), 3.73 (s, 6H), 3.62 (s, 3H), 2.31 (s, 3H). EIMS m/e 319 (M+, 69).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430062 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-fba63db1968c4ddca27f98a446829a40 |
| Source note | uspto-grants-1995_07 |