4-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) → 4-Ethyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1)

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Reaction Steps

From 109b (4.0 g, 13.2 mmol), a similar procedure as described in 110a gave 110b (3.17 g, 70.7%), as yellow crystals: mp 155°-7° C. after recrystallization from ethanol and methanol. 1H NMR (200 MHz, CDCl3) δ7.20 (s, br, 4H), 6.86 (s, 2H), 4.34 (s, 2H), 3.72 (s, 6H), 3.62 (s, 3H), 2.55 (q, J=8 Hz, 2H), 1.13 (t, J=8 Hz, 3H). Anal. (C18H24ClNO3).

Provenance & Evidence