HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) → 4-(Methylsulfanyl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) | HCID 373799 | — |
| Reactant | 4-(Methylsulfanyl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline | HCID 373808 | — |
| Product | 4-(Methylsulfanyl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) | HCID 373809 | 53.9% |
Reaction Steps
From 109e (3.0 g, 9.4 mmol), a similar procedure as described for 110a gave 110e (1.80 g, 53.9%) as yellow crystals: mp 194°-6° C. after recrystallization from ethanol:methanol:water. 1H NMR (200 MHz, DMSO-d6) δ7.23 (d, J=8 Hz, 2H), 7.07 (d, J=8 Hz, 2H), 6.83 (s, 2H), 4.30 (s, 2H), 3.73 (s, 6H), 3.62 (s, 3H), 3.62 (s, 3H), 2.40 (s, 3H). Anal (C17H22ClNO3S) C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05430062 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-468f2ea4153e4d9ea0f79bdba8b44819 |
| Source note | uspto-grants-1995_07 |