4-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) → 4-(Propan-2-yl)-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1)

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Reaction Steps

From 109f (6.0 g, 18.9 mmol), a similar procedure as described for 110a gave 110f (4.4 g, 65.9%), as yellow crystals: mp 160°-2° C. after recrystallization from methanol:ethanol:water. 1H NMR (200 MHz, CDCl3) δ7.35 (d, J=8 Hz, 2H), 7.29 (d, J=8 Hz, 2H), 6.92 (s, 2H), 4.37 (s, 2H), 3.73 (s, 6H), 3.63 (s, 3H), 2.88 (h, J=6 Hz, 1H), 1.17 (d, J=6 Hz, 6H). Anal. (C19H26ClNO3) C, H, N.

Provenance & Evidence