4-Methyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1) → 4-Propyl-N-[(3,4,5-trimethoxyphenyl)methyl]aniline--hydrogen chloride (1/1)

Participants

Reaction Steps

From 109g (6.0 g, 19.0 mmol), a similar procedure as described for 110a gave 110g (5.5 g, 82.5%) as yellow crystals, mp 118°-20° C. after recrystallization from ethyl acetate:methanol:hexane. 1H NMR (200 MHz, CDCl3) δ7.21 (d, J=8 Hz, 2H), 7.08 (d, J=8 Hz, 2H), 6.58 (s, 2H), 4.29 (s, 2H), 3.78 (s, 3H), 3.74 (s, 6H), 3.52 (t, J=8 Hz, 2H), 1.56 (sextet, J=8 Hz, 2H), 0.86 (t, J=8 Hz, 3H). Anal. (C19H26ClNO3) C, H, N.

Provenance & Evidence