1H-imidazole-2-carbaldehyde → HCID 178447373, compound

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Reaction Steps

The title compound was prepared from 3-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]butanamide hydrochloride dihydrate and 2-imidazolecarboxaldehyde by the procedure described in Example 1. Final purification carried was out by reverse phase HPLC on C18, eluting with methanol/0.1% aqueous trifluoroacetic acid using a linear gradient of 65% methanol to 80% methanol over ten minutes; retention time approximately 5.5 min. 1H NMR (200 MHz, CD3OD): δ1.41 (s, 3H), 1.45 (s, 3H), 2.0-2.7 (m, 6H), 4.37 (dd; 8, 12 Hz; 1H), 4.51 (s, 2H), 4.83 (d, 15 Hz, 1H), 5.23 (d, 15 Hz, 1H), 6.98 (d, 8 Hz, 2H), 7.1-7.4 (m, 7H), 7.4- 7.7 (m, 5H). FAB-MS: calculated for C33H35N9O2 589; found 590 (M+H, 83%).

Provenance & Evidence