HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1647362Generated: October 31, 2026
Methanol → 3-Amino-N-((phenylmethoxy)carbonyl)-L-alanine methyl ester
https://huagongshe.com/reaction/1647362
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Z-Dap-OH | HCID 2756313 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Amino-N-((phenylmethoxy)carbonyl)-L-alanine methyl ester | HCID 11043221 | — |
Reaction Steps
Dissolve Nα -(benzyloxycarbonyl)-β-(amino)-L-alanine (47.6g, 0.2mol) in methanol (500mL) and treat with concentrated sulfuric acid (0.5mL). Heat to 60° C. for 16 hours, cool and reduce the solvent by 50% in vacuo. Dilute with ethyl ether (500mL), wash with saturated sodium hydrogen carbonate, then brine. Dry (MgSO4) and evaporate the solvent in vacuo to give Nα -(benzyloxycarbonyl)-β-(amino)-L-alanine, methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05430145 |
|---|
| Source dataset | uspto-grants-1995_07 |
|---|
| ORD ID | ord-c68c5d86deba402aba900bc8b0f06a56 |
|---|
| Source note | uspto-grants-1995_07 |
|---|
