Pyridine → HCID 86748779, compound

HRID 1647380Notes

Reaction equation

HRID 1647380 reaction equation
N1C=CC=CC=1.[C:7](Cl)(=[O:9])[CH3:8].[NH2:11][C:12]1[C:25]2[N:24]([CH3:26])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17](=[O:27])[C:16]=2[C:15]([O:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:14][CH:13]=1>C(Cl)(Cl)Cl>[C:7]([NH:11][C:12]1[C:25]2[N:24]([CH3:26])[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17](=[O:27])[C:16]=2[C:15]([O:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[CH:14][CH:13]=1)(=[O:9])[CH3:8]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 86748780HCID 86748780, compound

Product 1

HCID 86748779HCID 86748779, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1.3 ml (16 mmol) of pyridine and 0.28 (4 mmol) of acetyl chloride are added to a solution of 0.7 g (2 mmol) of 4-amino-N-methyl-1-phenoxyacridone in 20 ml of chloroform, and the mixture is stirred at room temperature for 6 hours. The solution is washed with hydrochloric acid (18%), water and saturated aqueous sodium chloride solution, dried using sodium sulphate and evaporated. The residue is washed with diethyl ether nad filtered off. Yield: 0.6 g (83%) melting point: 252°-254° C.

Workup

  1. washThe solution is washed with hydrochloric acid (18%), water and saturated aqueous sodium chloride solution
  2. customdried
  3. customevaporated
  4. washThe residue is washed with diethyl ether
  5. filtrationnad filtered off

Sources & evidence

ORD record
ord-609641e72878448c965ce4af654d7fa1
Source dataset
uspto-grants-1995_07
Patent number
US05432049

Reaction notes

Loading…