1-Benzylpiperazine → 1-Benzyl-4-(benzothiophen-2-yl)piperazine

Beteiligte Stoffe

Reaktionsschritte

To a solution of 2-mercaptobenzothiophene (1.8 g, 10.8 mmol) in toluene under nitrogen was added N-benzylpiperazine (1.88 ml, 10.8 mmol) and the mixture heated at reflux for 1.5 h. Left to cool, concentrated in vacuo and product recrystallised from diethyl etherhexane to yield the title compound (1.55 g), m.p. 160°-161° C.

Herkunft & Nachweise