HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4,6-Bis(1,1-dimethylethyl)-5-[(2-methoxyethoxy)-methoxy]-2-pyrimidinecarbonitrile | HCID 19922986 | — |
| Product | 4,6-Bis (1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile | HCID 15294897 | 68.2% |
Reaction Steps
According to the procedure of Example 18, 4,6-bis(1,1-dimethylethyl) -5-[(2-methoxyethoxy)methoxy]-2-pyrimidine carbonitrile (9.1 g, 28.3 mmol) is treated with trifluoroacetic acid to give 4,6-bis(1,1-dimethylethyl)-5-hydroxy-2-pyrimidine carbonitrile (4.5 g, 68%); mp 203°-205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05432181 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-c489861f71f146a69ac58151c26e9de4 |
| Source note | uspto-grants-1995_07 |