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HRID1647441

反应详情

EQUATION

反应方程式

HRID 1647441 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccccc1N
HCID7242

2-Methylaniline

C7H9N

结构：C1COCCO1
HCID31275

1,4-Dioxane

C4H8O2

结构：CCCC(=O)c1cnc2c(COC(=O)c3ccc(OC)cc3)cccc2c1Cl
HCID10453445

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C(=O)OCc2cccc3cc(Nc4ccccc4)c(C)nc23)cc1
HCID86745483

未命名化合物

收率 90%

PROCEDURE

实验过程

A solution of 3-butyryl-4-chloro-8-(4-methoxybenzoyloxymethyl)quinoline (3.3 g, 8.3 mmol) and 2-methylaniline (1.33 ml, 12.4 mmol) in 1,4-dioxan (30 ml) was heated at reflux for 2 hours, then the dioxan evaporated and the product converted to free base. Recrystallisation from ethanol gave 3-butyryl-4-(2-methylphenylamino-8-(4-methoxybenzoyloxymethyl)quinoline (3.5 g, 90%), m.p. 135°-137°.

WORKUP

后处理

  1. temperatureat reflux for 2 hours
  2. customthe dioxan evaporated
  3. customRecrystallisation from ethanol