反应详情

A solution of ethyl 2-butyryl-3-(2-(1-hydroxyethyl)-phenylamino)acrylate (63 g, 0.2 mol) and pyridine (50 ml in dichloromethane (400 ml) were stirred at 0° C. and treated with benzoyl chloride (50 ml) in dichloromethane (100 ml) added at such a rate to keep the reaction temperature below 10° C. The cooling bath was removed and the mixture was stirred at ambient temperature for 2 hours. The solution was washed with 2M hydrochloric acid (×2), saturated sodium hydrogen carbonate solution, water and brine, dried (anhyd. MgSO4), filtered and evaporated-to an orange oil (70 g, 83%).

1. additionadded at such a rate
2. customthe reaction temperature below 10° C
3. customThe cooling bath was removed
4. washThe solution was washed with 2M hydrochloric acid (×2), saturated sodium hydrogen carbonate solution, water and brine
5. dry with materialdried (anhyd. MgSO4)
6. filtrationfiltered
7. customevaporated-to an orange oil (70 g, 83%)