HCID 178450481, compound → 3-butyryl-8-vinyl-4(1H)-quinolone

Participants

Reaction Steps

Ethyl 2-butyryl-3-(2-(1-benzoyloxyethyl)phenylamino)acrylate (70 g, 0.17 mol) was added dropwise to boiling diphenyl ether (700 ml) keeping the reaction temperature above 240° C. The mixture was heated under reflux for 1 hour then cooled rapidly. The mixture was chromatographed (silica gel, dichloromethane+methanol (2-4%)) to afford the required compound as a light solid (23.2 g, 56%) m.p. 206°-8° C.

Provenance & Evidence