Hydrochloric Acid → 1-[8-(2-Hydroxyethoxy)-4-(2-methylanilino)quinolin-3-yl]butan-1-one--hydrogen chloride (1/1)

Participants

Reaction Steps

3-Butyryl-4-(2-methylphenylamino)-8-(2-hydroxyethoxy)quinoline (10 g) was suspended in methanol (100 ml) at room temperature, cone. hydrochloric acid added slowly to give a clear solution, then the solvent evaporated. The residue was twice taken up in 2-propanol and re-evaporated, and was then recrystallised from 2-propanol/ether to obtain the desired salt (9.7 g), m.p. 214°-215° C.

Provenance & Evidence