Sodium Hydroxide → HCID 15337974, compound

Participants

Reaction Steps

5-tert-Butyl-2-[1-hydroxy-2-(4-methoxycarbonylphenoxy)ethyl]benzofuran (112 g) obtained in Example 1 was dissolved in 1.5 liters of methanol, a solution of 24.3 g of sodium hydroxide dissolved in 400 ml of water was added thereto and the mixture was heated to reflux for 2 hours. The reaction mixture was concentrated in vacuo, ice water was added to the residue and the mixture was acidified with concentrated hydrochloric acid to give crystals. The crystals collected by filtration were dissolved in ethyl acetate, the solution was washed with water and dried over anhydrous magnesium sulfate followed by concentrating in vacuo whereupon the residue is crystallized. This was dried and recrystallized from acetonitrile to give 88.3 g of crystals. M.p. 175°-177° C.

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