4-Hydroxybenzaldehyde → HCID 19925663, compound

Participants

Reaction Steps

p-Hydroxybenzaldehyde (12.2 g) was dissolved in 200 ml of N,N-dimethylformamide, 13.8 g of anhydrous potassium carbonate was added and, with stirring at room temperature, 28.1 g of 2-bromoacetyl-5-isopropylbenzofuran was added thereto within 30 minutes. The mixture was stirred at room temperature for 2 hours more. The reaction mixture was poured into aqueous solution of hydrochloric acid and the resulting crystals were collected by filtration and washed with water. The crystals were then dissolved in ethyl acetate, the solution was washed with water and the ethyl acetate layer was dried over anhydrous magnesium sulfate and concentrated in vacuo whereupon the residue was crystallized. Ether was added to the crystals and then collected by filtraton to give 18.1 g of crystals.

Provenance & Evidence