Hydrogen Bromide → HCID 19925668, compound

Participants

Reaction Steps

2-(4-Benzyloxycarbonylphenoxyacetyl)-5-tert-butylbenzofuran (1 g) obtained in Example 13 was suspended in 15 ml of acetic acid and 2 ml of 47% hydrobromic acid and the mixture was stirred at 60° C. for 15 hours. The reaction mixture was cooled, poured into ice water, the mixture was extracted with ethyl acetate, the extract was washed with water, dried over anhydrous magnesium sulfate, concentrated in vacuo, ether was added to the residue and the mixture was filtered followed by recrystallization from acetonitrile to give 510 mg of crystals. M.p. 209.5°-211° C.

Provenance & Evidence