Hydrochloric Acid → HCID 19925659, compound

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A methylene chloride (3 mL) solution of 4-{3-[4-(((4-methylpiperazinyl)carbonyl)-N-methylamino)phenylthio]phenyl}-4-methoxytetrahydropyran (132 mg, 0.29 mmol) was treated with a 4M solution of HCl in dioxane (7.3 mL, 0.29 mmol) and stirred at ambient temperature for 1 h. Addition of ether (20 mL) precipitated a colorless solid which was collected by filtration. The filter cake was washed thoroughly with ether and dried under vacuum to provide the title compound as a colorless solid. mp 154°-155° C.: 1H NMR (300 MHz, DMSO-D6) δ7.14-7.42 (5H, m), 3.63-3.77 (4H; m), 2.70-3.40 (8H; m), 3.16 (3H, s), 2.86 (3H, s), 2.72 (3H; br s), 1.80-1.93 (4H, m). MS m/e (M-HCl+H)+ =456; Analysis calc'd for C25H33N3O3S(2HCl): C, 56.81; H, 6.67; N, 7.95. Found: C, 56.91; H, 6.67; N, 7.56.

Provenance & Evidence