HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Chlorophenyl)-4-(piperidin-1-yl)butanenitrile → alpha-(2-Chlorophenyl)-alpha-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidine butanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Chlorophenyl)-4-(piperidin-1-yl)butanenitrile | HCID 11043596 | — |
| Reactant | N-(2-chloroethyl)-N-(1-methylethyl)benzenemethanamine, monohydrochloride | HCID 24185321 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | alpha-(2-Chlorophenyl)-alpha-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidine butanenitrile | HCID 11112943 | — |
Reaction Steps
alkylating α-(2-chlorophenyl)-1-piperidine butanenitrile with N-(2-chloroethyl)-N-(1-methylethyl)benzenemethanamine, monohydrochloride in the presence of base and dimethyl sulfoxide to give α-(2-chlorophenyl)-α-[2-[(1-methylethyl) (phenylmethyl)amino]ethyl]-1-piperidinebutane nitrile;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05432284 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-9dc16d8664ff409cbf686b37e19e6bc9 |
| Source note | uspto-grants-1995_07 |