Acetic Anhydride → Bidisomide

HRID 1647554Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([CH2:20][CH2:21][NH:22][CH:23]([CH3:25])[CH3:24])([CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:9]([NH2:11])=[O:10].[C:26](OC(=O)C)(=[O:28])[CH3:27]>>[C:26]([N:22]([CH:23]([CH3:25])[CH3:24])[CH2:21][CH2:20][C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])([CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:9]([NH2:11])=[O:10])(=[O:28])[CH3:27]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 13772091HCID 13772091, compound

Product 1

HCID 59798Bidisomide

Procedure

acetylating α-(2-chlorophenyl)-α-[2-[(1-methylethyl)amino]ethyl]-1-piperidinebutanamide in the presence of acetic anhydride to give α-[2-[acetyl (1-methylethyl)amino]ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide.

Sources & evidence

ORD record: ord-8eaec709b81b473191184b931ae6f02e
Source dataset: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05432284

Reaction notes

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