5-Methylthiazole → HCID 10461467, compound

HRID 1647578Notes

Reaction equation

HRID 1647578 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=[O:33])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:13]=1.[CH3:34][C:35]1[S:39][CH:38]=[N:37][CH:36]=1>C1(C)C=CC=CC=1>[Br-:1].[CH3:34][C:35]1[S:39][CH:38]=[N+:37]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:9][C:10](=[O:33])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH:13]=2)[CH:36]=1

Participants

4

Reactant 2

HCID 1379805-MethylthiazoleHCID 10255988HCID 10255988, compound

Product 1

HCID 10461467HCID 10461467, compoundYield 98.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 2.3 g of N-[2-(bromomethyl)phenyl]-3-(tetradecyloxy)benzeneacetamide and 2.21 g of 5-methylthiazole in 40 ml of toluene is refluxed for 2.5 hours under argon. The solvent is evaporated to a residue which is mixed with ether and the resulting solid collected by centrifugation, washed with ether then dried to give 2.7 g of the desired product as a white powder, m.p. 94°-100° C.

Workup

  1. temperatureis refluxed for 2.5 hours under argon
  2. customThe solvent is evaporated to a residue which
  3. additionis mixed with ether
  4. customthe resulting solid collected by centrifugation
  5. washwashed with ether
  6. customthen dried

Sources & evidence

ORD record
ord-2950a8e961634c01b8095efa1f6ae116
Source dataset
uspto-grants-1995_07
Patent number
US05432189

Reaction notes

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