Ammonia → 2-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Participants

Reaction Conditions

Reaction Steps

4.4 g (0.259 mol) of ammonia gas were passed into a mixture of 26.0 g (0.1293 mol) of 2,4-difluoro-6-trifluoromethoxy-1,3,5-triazine in 100 ml of tetrahydrofuran in the course of 45 minutes at from -70° to -65° C. while stirring. Stirring was carried out for 2 hours at -70° C. and overnight while the mixture warmed up to 22° C. The mixture was evaporated down under reduced pressure, after which the residue was stirred with water, filtered off under suction and washed. Drying gave 22 g (85.9% of theory) of the title compound of melting point 138°-139° C.

Provenance & Evidence