Sodium Methoxide → 2-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

HRID 1647665Notes

Reaction equation

HRID 1647665 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103932-Amino-4-methoxy-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9.1 g (0.05 mol) of 30% strength sodium methylate were added to a mixture of 10 g (0.05 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 100 ml of methanol at 0° C. in the course of 15 minutes while stirring. Stirring was continued for one hour at 0° C., after which the mixture was evaporated down under reduced pressure, the residue was taken up in methylene chloride and the solution was extracted with water. Drying and evaporating down gave 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.

Workup

  1. stirringStirring
  2. customafter which the mixture was evaporated down under reduced pressure
  3. extractionthe solution was extracted with water
  4. customDrying
  5. customevaporating down gave 10.5 g (99% of theory) of the title compound of melting point 96°-101° C.

Sources & evidence

ORD record
ord-9b8e95a333064f6ba6c0dc37561a0661
Source dataset
uspto-grants-1995_07
Patent number
US05434124

Reaction notes

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