Sodium Methoxide → HCID 67783632, compound

HRID 1647666Notes

Reaction equation

HRID 1647666 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7](F)[N:6]1[O:13][CH:14]([F:16])[F:15]>CO>[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7]([O:2][CH3:1])[N:6]1[O:13][CH:14]([F:16])[F:15]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 67783290HCID 67783290, compound

Product 1

HCID 67783632HCID 67783632, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8.4 g (0.047 mol) of 30% strength sodium methylate were added to a mixture of 10 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine in 100 ml of methanol at 0° C. in the course of 15 minutes while stirring. Stirring was continued for one hour at 0° C. after which the mixture was evaporated down under reduced pressure, the residue was taken up in methylene chloride and the solution was extracted with water. Drying and evaporating down gave 10.4 g (98.5% of theory) of the title compound of melting point 109°-110° C.

Workup

  1. stirringStirring
  2. customafter which the mixture was evaporated down under reduced pressure
  3. extractionthe solution was extracted with water
  4. customDrying
  5. customevaporating down gave 10.4 g (98.5% of theory) of the title compound of melting point 109°-110° C.

Sources & evidence

ORD record
ord-ad2a561871894bd596cfcf632a510f22
Source dataset
uspto-grants-1995_07
Patent number
US05434124

Reaction notes

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