Dimethylamine → 2-Amino-4-dimethylamino-6-trifluoromethoxy-1,3,5-triazine

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Reaction Steps

5.0 g (0.111 mol) of gaseous dimethylamine were passed into a solution of 11 g (0.055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 150 ml of tetrahydrofuran in the course of 20 minutes at 0° C. while stirring. Stirring was continued for one hour at 0° C. and overnight at 22° C. Evaporating down, washing with water and drying gave 9.9 g (80.7% of theory) of the title compound of melting point 114°-118° C. (decomposition).

Provenance & Evidence