Dimethylamine → HCID 86747119, compound

Participants

Reaction Steps

1.9 g (0.0417 mol) of gaseous dimethylamine were passed into a mixture of 8.9 g (0.0417 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoropyrimidine in 100 ml of tetrahydrofuran in the course of 10 minutes at 0° C. while stirring. Stirring was continued for 1 hour at 0° C. and for 2 hours at 25° C. Working up in the conventional manner gave 9.7 g (97.5% of theory) of the title compound of melting point 127°-130° C.

Provenance & Evidence