Water → HCID 19920944, compound

Participants

Reaction Steps

Dissolve 3-(benzenesulfonyl-{3-[butyl-(2-mercapto-ethyl)-amino]-propyl}-amino)-N-butyl-proponamide (10 mmol) prepared in Scheme VII, step B in 1,2-dimethoxyethane (50 mL) and treat with lithium aluminum hydride (20 mmol). Heat the re action to reflux for 18 hours. After cooling the react ion is worked up by consecutive addition of water (0.8 mL), 10% sodium hydroxide (1.2 mL) and water (2 .2 mL). Then dilute with methylene chloride (200 mL), rinse with water (100 mL), brine (100 mL), dry over anhydrous sodium sulfate, filter and concentrate under vacuum. Purify the residue by flash chromatography (silica gel, methanol/methylene chloride) to provide the title compound.

Provenance & Evidence