Iodine → HCID 178508989, compound

HRID 1647709Notes

Reaction equation

HRID 1647709 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1.O.[OH-].[Na+].[I:18]I>C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([I:18])=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1

Participants

6

Reactant 4

HCID 807IodineHCID 962WaterHCID 14798Sodium HydroxideHCID 178508962HCID 178508962, compound

Product 1

HCID 178508989HCID 178508989, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Following the procedure of Example 16 but substituting 21.4 g. (0.113M) of 2-amino-6-phenyl-4-pyrimidinol, 200 ml. water, 500 ml. chloroform, 5.6 g. sodium hydroxide and 28.8 g. I2, a yield of 29.0 g. (78%) of 2-amino-5-iodo-6-phenyl-4-pyrimidinol is obtained.

Sources & evidence

ORD record
ord-f65016d6a7a7405ba1da474939737a25
Source dataset
uspto-grants-1995_07
Patent number
US05434157

Reaction notes

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