Zincchloride → HCID 178508990, compound

HRID 1647710Notes

Reaction equation

HRID 1647710 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([I:9])=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1.O(C)[Na].CO.[Cl-].[Zn+2:22].[Cl-]>CO>[Zn:22].[NH2:1][C:2]1[N:7]=[C:6]([OH:8])[C:5]([I:9])=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:3]=1

Participants

5

Reactant 3

HCID 3007855ZincchlorideHCID 178501943HCID 178501943, compoundHCID 178508989HCID 178508989, compound

Product 1

HCID 178508990HCID 178508990, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 1.56 g. (5 mmole) of 2-amino-5-iodo-6-phenyl-4-pyrimidinol in 15 ml. of methanol under nitrogen with stirring at room temperature is added 1.1 ml. of a 25% NaOCH3 /CH3OH solution. After five minutes 340 mg. (2.5 mmole) of anhydrous zinc chloride (ZnCl2)) was added. After one hour the heterogeneous solution is concentrated to dryness, washed with 2×50 ml. water, filtered, and dried in vacuo at 60° C. for 18 hours. The product is a white solid with m.p. at 285° C.

Workup

  1. additionis added 1.1 ml
  2. concentrationAfter one hour the heterogeneous solution is concentrated to dryness
  3. washwashed with 2×50 ml
  4. filtrationwater, filtered
  5. customdried in vacuo at 60° C. for 18 hours
  6. customat 285° C.

Sources & evidence

ORD record
ord-2f941d14b4874f1f89be9bde0577b3a0
Source dataset
uspto-grants-1995_07
Patent number
US05434157

Reaction notes

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