Chloroform → HCID 14207290, compound

Participants

Reaction Steps

3.79 Grams (10 mM) of 6-[2-(1-phenyl-2-imidazolyl)sulfinylacetyl]-3,4-dihydrocarbostyril was dissolved in a mixture of 240 ml of acetic acid with 100 ml of water, then 5.06 g (32 mM) of potassium permanganate was added thereto. This mixture was stirred at room temperature for 2 days. After the reaction was completed, chloroform was added to the reaction mixture and filtered with Celite (a trademark for distomaceous earth product, manufactured by Johns-Manville Proudcts Corp.). The filtrate was washed with water and dried with anhydrous magnensium sulfate. The residue obtained by removing the solvent was purified by means of a silica gel column chromatography (eluent: chloroform:methanol=30:1), and recrystallized from ethanol-chloroform to yield 0.6 g of 6-[2-(1-phenyl-2-imidazolyl)sulfonylacetyl]-3,4-dihydrocarbostyril. Light yellow granular substance. Melting point: 199°-201° C.

Provenance & Evidence