Dimethylamine → HCID 67619892, compound

HRID 1647840Notes

Reaction equation

HRID 1647840 reaction equation
[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][NH:7][C:8](SC)=[CH:9][N+:10]([O-:12])=[O:11])[CH2:2]1.[CH3:15][NH:16][CH3:17]>C(#N)C>[O:1]1[CH2:5][CH2:4][CH:3]([CH2:6][NH:7][C:8]([N:16]([CH3:17])[CH3:15])=[CH:9][N+:10]([O-:12])=[O:11])[CH2:2]1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 67619523HCID 67619523, compound

Product 1

HCID 67619892HCID 67619892, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture comprising 4.0 g of 1-[{(tetrahydro-3-furanyl)methyl}amino]-1-methylthio-2-nitroethylene, 10 ml of 50% aqueous dimethylamine solution and 50 ml of acetonitrile was stirred at room temperature for an hour. The reaction mixture was concentrated under a reduced pressure, and purified by silica gel column chromatography (eluent: ethyl acetate/acetone=1/1) to obtain 2.8 g of 1-[{(tetrahydro-3-furanyl)methyl}amino]-1-dimethylamino-2-nitroethylene.

Workup

  1. concentrationThe reaction mixture was concentrated under a reduced pressure
  2. custompurified by silica gel column chromatography (eluent: ethyl acetate/acetone=1/1)

Sources & evidence

ORD record
ord-ca736924ae19427ab96dd74c3141d807
Source dataset
uspto-grants-1995_07
Patent number
US05434181

Reaction notes

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