HuagongsheHuagongshe Chemistry Print Report · For research reference only
S,N-dimethyl-N'-nitroisothiourea → HCID 137226518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | S,N-dimethyl-N'-nitroisothiourea | HCID 11051832 | — |
| Reactant | N-Ethyltetrahydro-3-furanmethanamine | HCID 22355252 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 137226518 | HCID 137226518 | 23.8% |
Reaction Steps
A mixture comprising 5.5 g of N-{(tetrahydro-3-furanyl)methyl}-N-ethylamine, 3.0 g of S-methyl-N-nitro-N'-methyisothiourea, 30 ml of ethanol and 0.5 g of DMAP was refluxed for 4 hours. Then, the reaction fluid was concentrated under a reduced pressure to obtain an oily matter, which was purified by column chromatography. 1.1 g of 1-{(tetrahydro-3-furanyl)methyl}-1-ethyl-2-nitro-3-methylguanidine were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05434181 |
| Source dataset | uspto-grants-1995_07 |
| ORD ID | ord-e9aa342d44b642a6b7382ce1193c0bbd |
| Source note | uspto-grants-1995_07 |