2-(Bromomethyl)tetrahydro-2H-pyran → 1'-[(2-isopropyl-1,3-thiazol-5-yl)methyl]-7'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 164785Notes

Reaction equation

HRID 164785 reaction equation
[Br:11][CH2:12][CH:13]1[CH2:14][CH2:15][CH2:16][CH2:17][O:18]1.[Cl:1][CH2:2][c:3]1[cH:4][n:5][c:6]([CH:8]([CH3:9])[CH3:10])[s:7]1.[F:19][C:20]([c:21]1[cH:22][cH:23][cH:24][c:25]2[c:26]1[NH:27][C:28](=[O:41])[C:29]21[CH2:30][O:31][c:32]2[c:33]1[cH:34][c:35]1[c:36]([cH:40]2)[O:37][CH2:38][O:39]1)([F:42])[F:43]>>[CH2:2]([c:3]1[cH:4][n:5][c:6]([CH:8]([CH3:9])[CH3:10])[s:7]1)[N:27]1[c:26]2[c:21]([C:20]([F:19])([F:42])[F:43])[cH:22][cH:23][cH:24][c:25]2[C:29]2([C:28]1=[O:41])[CH2:30][O:31][c:32]1[c:33]2[cH:34][c:35]2[c:36]([cH:40]1)[O:37][CH2:38][O:39]2

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 152908765-(Chloromethyl)-2-(propan-2-yl)-1,3-thiazoleHCID 685972007'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Product 1

HCID 593521701'-[(2-isopropyl-1,3-thiazol-5-yl)methyl]-7'-(trifluoromethyl)spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-f0ae3bf7fde4437598791969af115368
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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