HCID 19921222, compound → HCID 67805268, compound

Participants

Reaction Steps

0.8 g of 2-(4-aminomethyl-phenyl)-1-(3-amino-propyl)-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-benzimidazole are left to stand for 20 hours at ambient temperature in 10 ml of 48% hydrobromic acid. The mixture is concentrated by evaporation in vacuo and the residue is purified by chromatography on silica gel (eluant:n-butanol/glacial acetic acid/water=4:1:1 to 4:2:2). Yield: 0.6 g (67% of theory), Rf value: 0.66 (Reversed Phase Plate RP18; methanol/5% sodium chloride solution/conc. hydrobromic acid=6:10:0.01)

Provenance & Evidence