Bis(trifluoroacetoxy)iodobenzene → HCID 54502024, compound

HRID 1647903Notes

Reaction equation

HRID 1647903 reaction equation
N[C:2]([C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:17]([CH3:18])[C:16]3[CH:19]=[CH:20][C:21]([C:23]([NH:25][CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29])=[O:24])=[CH:22][C:15]=3[N:14]=2)=[CH:9][CH:8]=1)([CH3:6])C)=O.FC(F)(F)C(OI(C1C=CC=CC=1)OC(=O)C(F)(F)F)=O.C(#[N:55])C.O>>[NH2:55][C:4]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[N:17]([CH3:18])[C:16]3[CH:19]=[CH:20][C:21]([C:23]([NH:25][CH2:26][CH2:27][C:28]([O:30][CH3:31])=[O:29])=[O:24])=[CH:22][C:15]=3[N:14]=2)=[CH:9][CH:8]=1)([CH3:6])[CH3:2]

Participants

4

Reactant 3

HCID 102317Bis(trifluoroacetoxy)iodobenzeneHCID 18373917Acetonitrile--water (1/1)HCID 54029314HCID 54029314, compound

Product 1

HCID 54502024HCID 54502024, compound

Procedure

Prepared from 2-[4-(2-aminocarbonyl-2-propyl)-phenyl]-5-[(2-methoxycarbonyl-ethyl)-aminocarbonyl]-1-methyl-benzimidazole by treating with [bis(trifluoroacetoxy)-iodo]benzene in acetonitrile/water at ambient temperature.

Sources & evidence

ORD record
ord-72028d373efb4e749275ffbd23cb3a66
Source dataset
uspto-grants-1995_07
Patent number
US05434150

Reaction notes

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